The attack was the second deadly attack in a prominent Pakistan city this week, after a suicide blast claimed by the Pakistani Taliban at one of the country's oldest and most popular Sufi shrines killed at least 12 people in the eastern city of Lahore.
He said the roads leading to Koh-i-Batil, the hill on which the five-star hotel is located, had been closed by a heavy contingent of security forces.
Beijing has built and operates the massive Gwadar port under a multi-billion-dollar bilateral mega-project, known as China-Pakistan Economic Corridor (CPEC).
The hotel came under attack as some armed militants on Saturday stormed its premises on Saturday evening.
Security forces made special entry points to get into 4th floor, shot down all terrorists and cleared planted IEDs, the statement added.
Earlier reports said there had been four attackers.
All the guests were safely evacuated from the hotel.
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The newly formed separatist Baloch Raji Aajoi Sangar group claimed responsibility for an April 18 attack that killed 14 passengers on a bus on a remote coastal highway in the restive province.
Prime Minister Imran Khan called the attack an act of terrorism and praised the "initial response by security guards and security forces" for preventing greater loss of life.
The terrorists had attempted to enter the hotel to take hostage the guests present in the hotel, according to the ISPR.
"No foreigners are staying in the hotel".
Senior security officials had said the four attackers were killed.
The province, the country's poorest, has always been known to be at risk due to activities by militants, which include the Pakistani Taliban and other terrorist groups, according to the BBC.
Security across most of Pakistan has improved over recent years following a major crackdown after the country's worst attack, when some 150 people, majority children, were killed in an assault on a school in the western city of Peshawar in 2014. The massive infrastructure project seeks to connect the western Chinese province of Xinjiang with Gwadar, on the Arabian Sea.