His absence is likely to provide an opportunity for Andreas Christensen to start alongside David Luiz, while opening the door for club captain Gary Cahill - who has not made a competitive appearance since November - to return to the bench.
Meanwhile, Germany global Rudiger will miss the remainder of the season, having suffered a repeat of a previous knee injury in Sunday's 1-1 draw at Manchester United.
Speaking about his side's defensive issues, Sarri said: "We are in trouble with the centre-backs".
Sarri explained: "Cahill is out with a problem with his Achilles tendon".
Kepa Arrizabalaga continues in goal for the Blues against Eintracht Frankfurt, but there are a couple of changes in the backline shielding him, one of which is enforced. We've played 58 matches this season and, in the past, we've been lucky with injuries.
Minneapolis officer convicted of murder in 911 caller death
Noor, 33, testified last week that he opened fire because he feared he and his partner were being ambushed. Harrity was behind the wheel of their squad auto when Noor shot Ruszczyk from the passenger seat.
"He's played very important matches very well so he isn't the problem". I don't want to play the final.
Earlier, Legit.ng had reported how Premier League giants Chelsea were tipped by the supercomputer to win the 2018/19 Europa League title after landing in the semifinal of the competition.
'I've seen Eintracht's games in the Europa League, and they are risky. We played very well for 35 minutes in the second half, so I think in the end we deserved the win - but 1-1 away is not so bad. We don't know at the moment which is the right way [to qualify] because we can get into the Champions League by the Premier League or by the Europa League,"Sarri said".
- With the Premier League title and relegation still in the balance going into the penultimate game of the season, could we see any shocks this weekend?
"I am very happy with the performance but not with the result", he said.