This was Tottenham's sixth league game of the season in which Kane has not been in the starting line-up (five of those he has missed entirely, with one 16-minute substitute cameo against Leicester City in August).
But Pochettino says the two injuries are distinct.
And he completed his hat-trick deep into injury time with another emphatic finish past Hamer.
"We have to make sure the players on the pitch have full energy".
"They do get him back very quickly, but they wouldn't send him out if he wasn't ready".
"You always think about the reasons why we are where we are, all that kind of stuff". That's the plan now.
"The massive risk is how we are going to approach the game tomorrow".
Luke Walton and Magic Johnson haven't spoken in weeks
Toronto Raptors forward OG Anunoby has undergone an emergency appendectomy after being diagnosed with acute appendicitis. If this was his curtain call in Charlotte , Walker certainly left Hornets fans with a memory of what they'll miss.
"Thank you to the fans for making the first two games at the new stadium very memorable".
City's need for a goal on Wednesday could also see them push forward and risk being exposed by Son and Moura's pace.
When asked if he believes Kane could return this season, the manager said: "We'll see, there is five weeks, it is going to be hard". He saw a specialist on Thursday and is more likely to return for next week's second leg against Manchester City.
South Korea forward Son did not take long to prove Tottenham aren't a one-man team as he hit the victor against City after Kane went off.
Moura grabbed his first with 27 on the clock and then struck twice late on to become the first player to score a treble in Spurs' new stadium.
Terriers boss Jan Siewert optimistically claims Tottenham could be inhibited by their injury problems.
Meanwhile, Huddersfield defender Chris Lowe, who joined on a free transfer in 2016 and helped them earn promotion, said confirmation of relegation had done little to change the mood around the club given they had known it was coming for so long. "In a way it makes it more hard", Siewert said.