Defending champion Isner advances to 4th round at Miami Open

Naomi Osaka of Japan returns to Yanina Wickmayer of Belgium during the Miami Open tennis tournament Friday

Serena Williams pulls out of Miami Open with knee injury

Su-Wei Hshieh of Chinese Taipei waves to the crowd after her match against Naomi Osaka of Japan (not pictured) in the second round of the Miami Open at Miami Open Tennis Complex.

In was the second win over Kerber in less than a week for the 18-year-old Andreescu, who also beat the German in the final of the BNP Paribas Open. She regrouped and now has won 63 consecutive matches when she takes the first set. Hsieh pulled off a 4-6, 7-6 (4), 6-3 shocker.

Williams played poorly for a stretch and was broken three times but steadied her game in the final set to beat Rebecca Peterson 6-3, 1-6, 6-1.

"I just think I got too emotional, which is something I did last match, too", she said.

No. 2-seeded Alexander Zverev double-faulted 12 times and lost to wildcard David Ferrer, 6-2, 5-7, 3-6. "I thought, 'This must be good light.' I thought about taking a selfie, but you've got to stay in the moment".

Until 2018, Hsieh had no victories over Top 5 players to her name, but in the last 14 months, Hsieh has notched four wins over that cohort.

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Seeded losers on the men's side included No. 10 Karen Khachanov, No. 21 Diego Schwartzman, No. 26 Guido Pella, No. 30 Stan Wawrinka and No. 31 Steve Johnson. Her only other win over a number one player came against Simona Halep at Wimbledon a year ago. No. 3-seeded Dominic Thiem lost his opening match to Hubert Hurkacz 6-4, 6-4. "I went in thinking everything was on my racket". She has the ability to make winners too whenever she wants. Defending champion Sloane Stephens beat Ons Jabeur 6-2, 6-3 and three-time victor Venus Williams overcame a wobbly start to beat No. 24 Carla Suarez Navarro 7-6 (7-4), 6-1.

In a short stretch on Saturday afternoon, the women's draw of the Miami Open lost its two biggest attractions - though only one was playing.

Two weeks ago, the 23-time grand slam champion retired from her third-round Indian Wells match against Garbine Muguruza citing "extreme dizziness and extreme fatigue", which tournament organizers later identified as a virus. In Australia, honestly she should have won but I found a way to win it. Williams, 37, still hasn't won a tournament since the 2017 Australian Open, before she took a break of more than a year to become a mom.

Her troubles, however, pale in comparison with Williams, who has completed just seven matches this year, and issued a brief statement to express her "disappointment".

Earlier, South Africas Kevin Anderson made a winning return to competition with a 6-4, 3-6, 6-3 victory over rising Spaniard Jaume Munar.

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