That advantage was increased to 36 points by the hour mark as England's kicking game continued to expose French frailties.
The die of England's go-to attacking tactic was cast in the opening exchanges and France failed to find any answers.
Kicks behind the French defence on a rainswept pitch proved the visitors' undoing, with May repeatedly tormenting opposing wing Damian Penaud.
England notched a four-try victory over an Ireland team high on confidence in its opening game in Dublin before backing that up with a comprehensive 44-8 win over an ailing French outfit at Twickenham, London. "To score a hat trick at Twickenham is awesome and very special, I'm very lucky".
Against the team who won the grand slam previous year, England raced into a 24-0 lead by scoring four first-half tries yesterday with a performance that Simon Middleton, the head coach, said came close to achieving his side's potential.
"But I think it is not just us, and we are not alone in this disaster", the 20-time global added.
First half hatrick. Phenomenal half from the whole @EnglandRugby squad.
Meanwhile Yoann Huget - played out of position at full-back - was substituted at half-time by France coach Jacques Brunel. "If somebody had said it was going to be 24-0 at half-time, I would have been surprised", Middleton said.
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"We are two (wins) from two, and we have a couple of weeks of training before England".
So many of their players are in excellent form including Owen Farrell and winger Jonny May who scored three tries this afternoon.
Under Brunel's stewardship, France have lost nine of their last 10 tests, which have included a first-ever loss to Fiji, their biggest defeat to England in more than a century, a second half capitulation which led to defeat against Wales, and a three-match series pummelling at the hands of New Zealand a year ago.
Farrell's conversion hit the post but England were 16-3 up.
This time Farrell kicked the conversion and England were nearly out of sight at 23-3.
This time a kick through from scrum-half Ben Youngs found Ashton in a huge amount of space an although the former Toulon player was hauled down short of the line, the ball came back to Slade, who cut inside for a converted try.
He would have been listed as a try scorer had he not been unceremoniously brought to ground without the ball by Gael Fickou with Ashton favourite to win the chase and touch down in the second-half - a penalty try being awarded and the Frenchman sin-binned.
With the title already well out of their reach, Les Bleus must now avoid defeat against Scotland at the Stade de France on February 23 if they do not want to play a "wooden spoon" clash in Rome against Italy in their last outing.