Messi was uncharacteristically off the mark from deadball situations, while strike partner Suarez continued his woeful form away from home in the competition.
Ousmane Dembele forced a save from host keeper Anthony Lopes in the 19th minute and grazed the post with a shot in the final stretch of the first half, which also saw Lyon defender Jason Denayer deny Sergio Busquets when the keeper was caught out of position.
More alarmingly, he's scored just once in his last 17 Champions League appearances and is without an away goal in the tournament since 2015 - a run which has now moved beyond the 25-hour mark. "The tie is in the air, 0-0 is a unsafe result, we will not kid ourselves", Valverde told Movistar. A 0-0 is a rather good result ahead of the return leg'.
Barca head coach Valverde is not concerned, however.
The La Liga leaders dominated the match but lacked accuracy up front; Lionel Messi, unusually, had an off day while Luis Suarez's difficulties away from home in Europe's premier club competition continue.
"I do not think it is very easy to win away from home in the Champions League".
With Fekir absent, Lyon will be relying on the flicks and tricks of Dutch forward Memphis Depay and French-Algerian youngster Houssem Aouar to poke a hole through Barcelona's defence.
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Five minutes later, Diego Godin put the game to bed by firing home a shot from a tight angle that took a deflection off Ronaldo. Juventus will bid to overturn a two-goal deficit in the return leg in Turin on March 12.
Spanish newspaper Marca rated Suarez as the worst Barcelona player on the pitch against Lyon, adding: "It wasn't his night as he was slow and off colour throughout".
'We know that he has what it takes, technically, to help us and to get that goal for us, ' said manager Bruno Genesio.
But he had a largely frustrating first half, failing to test Lopes with a free kick and two shots.
Barça has the best team, however, and will be expected to qualify despite all the problems they'll face against a really good Lyon team.
Finally, he highlighted Lyon's quality: "They have not lost a game in the Champions League".
And such wastefulness was almost punished, with Lyon no mugs and looking to hit Barcelona on the break whenever they could.
Valverde was happy with his team's performance but said he was frustrated to see so many missed many opportunities.