The EU immediately warned that the vote raises the risk of a hugely disruptive "no deal" Brexit where Britain could sever ties with its biggest trading partner overnight.
May's Brexit deal suffered a crushing defeat in parliament on Tuesday, triggering political chaos that could lead to a disorderly exit from the European Union, a reversal of the 2016 decision to leave or a compromise deal of some sort. That's more than a third of the membership of the House of Commons.
Sterling jumped by more than a cent against the US dollar on news of May's Brexit deal defeat on Tuesday and was holding close to that level on Wednesday.
"The events in Parliament today are really quite remarkable", said Cambridge University political historian Luke Blaxill.
"We will have to negotiate a transition period with them because the British can not afford to no longer have planes taking off or landing at home", he said.
With the ruling Conservative party divided, the opposition party holds great influence over the eventual outcome of Brexit.
Rob Ford, a professor of politics at Manchester University, stressed that these were odd times. Tuesday's volatile session saw the pound swing from a peak of $1.2917 in Asian trade, to a drop to $1.2670 just ahead of the vote. "At every turn the prime minister has closed the door on dialogue", Corbyn said. "But that's clearly not going to happen", Ford said. On Tuesday night, 118 members of her party voted against her deal. Desmond Swayne, one of those pledged on to vote down the deal, said he might back it to ensure Britain leaves the bloc. She survived that vote unscathed.
But critics said she was not budging from a deal that had alienated all sides of the debate.
January 9, 2019 - After returning from the Christmas break, MPs begin five days of debate on the PM's deal.
Meghan Markle goes from $45 H&M dress to glittering evening gown
The duchess is a dog lover who supported various animal rescue centres in her home city of Los Angeles. The dress also didn't stop Markle from petting the dogs in the animal shelter while she visited.
"We must find a solution that commands sufficient support in this house", she said.
The defeat on the deal could lead to renegotiations with Brussels on a new deal even if Mrs May stays on.
The lead candidate of the EPP for the commission presidency, Weber gave way to the frustration felt by many in the European Union when he said: "Please, please, please tell us finally what you want to achieve".
As well as Mr Tusk's tweet, there has been plenty of comment on Tuesday's vote from across Europe.
A graphic explains the various Brexit options now that Theresa May's proposed exit deal failed its vote. But the path to getting there remains long and complicated. Nevertheless, French President Emmanuel Macron has ruled out any further concessions for the United Kingdom, saying the European Union had "reached the maximum" of what could be offered in terms of a Brexit deal. An extension would require unanimous consent from the remaining European Union countries.
"It's right for the prime minister to have discussions across parties as we need to get a consensus about how to go forward".
"The British people already voted on Brexit emphatically back in 2016". As members hooted and jeered, the speaker gaveled them to be quiet, complaining of the "noisy and unseemly atmosphere".
Labour's headquarters in London described as inaccurate claims the party doesn't have an alternative plan. Now he said he felt the same duty to confront his neighbors over Brexit.
"The public deserve so much better than this choice in the broken political system than they are being given", he said.
"Plus, you choose the team, you choose the team that will take us forward".
Outside Parliament, the scene was raucous. Another man in the crowd suggested that the prime minister should face the executioner's ax.