Joe Gomez and Joel Matip have both suffered injuries that will keep them out until the year.
Gini Wijnaldum is another who is equipped to play in a deeper role but Fabinho is the most likely candidate in the current squad to solve this mini crisis and see Liverpool through potentially choppy waters.
Fans took to twitter to have their say on his new stone cold celebration and the sensational form the Liverpool prodigy is now showing.
The save was worth nearly £11m to Liverpool - in terms of money for the victory and qualification - and Klopp insisted the Brazil global has already proved an astute investment.
Ancelotti's team will qualify from Group C if they avoid defeat at last season's finalists Liverpool on Tuesday, or if they lose and Paris Saint-Germain are also beaten at Red Star Belgrade.
In total last season, United conceded just 28 goals in league play.
Emery hails 'hungry' Torreira as Arsenal grind down Huddersfield
Arsenal are next in Europa League action with a home clash against Qarabag, a game followed by a trip to Southampton on Sunday. But the flip side of that is they're lacking in match practice so could really do with the run-out on Thursday.
"I've been going to almost every home game for about five or six years now".
As for United, they have struggled in games between the so-called big six sides this season and are the only team yet to record a victory in these fixtures.
Fascinatingly, the 26-year-old has a special way of interpreting key moments, disclosing that he can only see bits of moments upclose. Phil Jones' embarrassing own-goal in the 2-1 loss to Valencia in the Champions League on Wednesday was the latest error at the back by United, which is stretched for resources in defence with Chris Smalling, Luke Shaw, Victor Lindelof and Marcos Rojo all injured.
So can Liverpool maintain their unbeaten start to the season and pick up their first win in nine meetings against their bitter rivals?
It's hard for people that can see to understand, but I think of it as normal to me and I have been like that all my life.
A positive 10 days for Wolves and West Ham also sees their stars feature, as many players are now starting to become regulars as we are almost halfway through the season.