Marcelo finally snapped their long spell without a goal by smashing into the net midway through the second half, scoring the club's first goal in 482 minutes, but despite creating more chances which saw Karim Benzema hit the woodwork and Mariano having a goal ruled out, Real could not find an equaliser.
And one would suspect that Lopetegui now regrets the decision to take the Madrid job, as he has not managed to guide the club through their transitional period and keep them near the top of the league.
Lopetegui's tenure at Real Madrid began with a 4-2 defeat in the Spanish Super Cup to city rivals Atletico Madrid and the European champions are fifth in the La Liga table, four points behind leaders Barcelona.
Prior to the September recess, they had scored 12 goals in four competitive fixtures, but subsequently they have mustered only five in seven games, three of which came at once against Roma in Europe.
Even though Lopetegui will take charge of Sunday's Camp Nou Clasico, president Florentino Perez is already arranging for his replacement to arrive.
Saudi Arabia has 'no intention' of 1973 oil embargo replay
Khashoggi , a US resident who fled Saudi Arabia past year , was an outspoken critic of Crown Prince Mohammed bin Salman . He said the Saudis did not know how Khashoggi , a Saudi national and US resident, had been killed or where his body was.
When asked about the possibility of being sacked after the game, the coach told reporters, "Right now, it's the last thing on my mind", the Coach said after the game.
And fans have now expressed their indignation on Twitter, with manager Julen Lopetegui now under serious pressure at the club.
"We have to sit down and think hard about what we are doing wrong and change our path". But we attacked a lot, and attacked very well.
Or does Lopetegui deserve more time at the helm?
"Some very unusual things happened as it sometimes does in football".