Cincinnati Mayor John Cranley said: "We send our prayers to the victims and their families".
A gunman opened fire at a bank in downtown Cincinnati Thursday morning, killing three people and injuring several more before he was also fatally shot.
Police say they don't know why 29-year-old Omar Enrique Santa Perez made a decision to open fire in the building.
The suspect was shot multiple times as four police officers approached.
Cincinnati Police tweeted that they are investigating the shooting which occurred in the lobby of Fifth Third Bank.
One of the victims died at the scene.
Cincinnati's Fountain Square will reopen Friday, just a day after a gunman opened fire at civilians at the nearby Fifth Third Center.
Al Jazeera contacted the Cincinatti Police Department but did not immediately receive a response. Leonard Cain tells The Cincinnati Enquirer that he was about to walk into the bank until someone told him about the shooting.
A witness said he heard up to 15 shots.
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September 6, 2018; Scenes from an active shooter situation in downtown Cincinnati at Fountain Square on Sept. 6, 2018.
It happened around 9 a.m. Thursday at Fifth Third Center on Walnut Street.
The Enquirer interviewed a person who said he saw a man firing a gun inside the bank lobby.
"I really feel sad that Rick didn't make it, but I did as much as I could to get help", Montoya told CNN affiliate WLWT.
He then saw a woman who was also walking into the bank. Isaac also said the suspect had a criminal record - all misdemeanors - in Cincinnati, as well as in SC and Palm Beach, Fla. "We're a bit rattled", said a Fifth Third Bank manager.
The Hamilton County Coroner's Office has identified those victims who lost their lives as 25-year-old Pruthvi Raj Kandepi, 64-year-old Richard Newcomer, and 48-year-old Luis Felipe Calderón. The hospital later said on Twitter that two of the four victims had died, another was in critical condition and the fourth was in serious condition. "You know, these are things that we see happening across the country, and we all have to be vigilant and prepared to deal with these situations". The bank building was locked down for most of the morning, and surrounding streets and sidewalks were closed off.
Cincinnati Mayor John Cranley said random people were targeted during the "horrific" attack. The company in a statement said it's working with law enforcement and offers thoughts and prayers for "everyone caught up in this bad event".
Cranley a year ago joined more than 1,000 mayors across the country in signing a pact to end illegal gun use and enforce current gun laws.