It is timed for release as the anticipation crests with Roger as returning champion, 10 years after their famed 2008 Wimbledon championship - an epic match so close and so reflective of their competitive balance that, in the end, the true victor was the sport itself.
Federer played first on Wednesday, then came Serena. "You have to win the last point, and I didn't succeed in that today".
The 32-year-old has made it to quarterfinals just twice in his career, including an appearance in last year's US Open final, where he lost to Rafael Nadal.
She is 36 and, against all odds, approaching the level that has brought her 23 grand slam titles, one short of the all-time record held by Margaret Court.
The Croat was stunned 3-6 1-6 6-4 7-6 (7-3) 7-5 by Argentina's world No.82 Guido Pella in three hours 12 minutes.
Defending champion Garbine Muguruza, second seed Caroline Wozniacki and two-time champion Petra Kvitova are amongst those that have suffered early exits and as a result, the women's draw is as open as it's been in more than half a century.
Compatriot Joe Salisbury is also through to round three with his partner Frederik Nielsen after their opponents Rohan Bopanna and Edouard Roger-Vasselin retired two sets and 3-2 down in the third.
Trump to order flags flown at half-staff to honor Capital Gazette victims
Friday morning's edition featured in-depth coverage of the shooting and obituaries of the five people killed. The president quickly issued a proclamation ordering the flags lowered nationwide until sunset on Tuesday.
Seven-times champion Williams rallied from 5-3 down in the second set to put away France's Kristina Mladenovic 7-5 7-6 (7-2).
The 38-year-old, seeded ninth, was a set and a break down but battled back to square the match, only to lose 8-6 in the decider.
Del Potro faces Benoit Paire in the third round after the Frenchman upset 26th-seeded Canadian Denis Shapovalov. "But I knew if I took my chances today, I could do well".
Three-time major victor Stan Wawrinka was unable to follow up his first round defeat of sixth seed Grigor Dimitrov when he lost 7-6 (9/7), 6-3, 7-6 (8/6) to Italian qualifier Thomas Fabbiano.
Dominic Inglot and Franko Skugor came through to win 6-3 4-6 7-6 (7-5) 2-6 6-2 in five sets against Fernando Gonzalez and Marcelo Demoliner.