"People in my family, people who look like me have put blood in the ground, have put martyrs in the dirt in this country to have it be liberty and justice for all", he continued, speaking on "Cuomo Prime Time".
But beyond shining a spotlight, it's unclear what the initiative will involve.
The First Lady traveled with President Trump for a follow-up briefing at FEMA headquarters on the ongoing hurricane response.
Trump tweeted it was falsely reported she faced "near death", had a "facelift", left the White House, or was abused by the president, and blamed "the Fake News Media" of being "unfair" and "so vicious" to the first lady after her recovery from surgery to treat a benign kidney condition.
For the past several weeks, rumors have swirled around the first lady's whereabouts after she underwent a kidney operation. Melania Trump stepped easily, smiled and was heard telling one worker "thank you very much".
Kim summit likely to be held at Singapore's Sentosa resort
Earlier, Trump told reporters that North Korean officials may come to Washington on Friday with a letter from Kim. On Thursday, Chol and Pompeo are scheduled to have full-day meetings at the White House.
However, two reporters who saw the first lady did report that they saw Mrs. Trump walking with aides at the White House.
In the video, you can see the man is in eye-sight of the president.
"It's an honor to be back at FEMA with you and the first lady", said Pence.
The first sighting of the first lady.
CNN's "New Day" co-host John Berman complained Monday, "We're told she will be at a White House event tonight, but we won't see her". But she's hopeful the campaign will help promote efforts to collect and dispose of unused prescription pain medications. "She's done a fantastic job as first lady". "And we're very proud of her".
Another group working on the issue is Lily's Place, a treatment center in West Virginia for infants exposed to opioids, which the first lady visited a year ago. Mrs Trump spent five days in hospital after her successful surgery.