Nadal mentioned afterward he was positive Zverev - mentored by six-time grand slam victor Boris Becker - would expertise success at grand slams quickly however Lajovic initially didn't learn the script.
After squandering two break-point chances, Zverev made amends in the Russian's following service game in the second set to take command but Khachanov hit back on his fifth break point when the German served for the second set to secure the break back.
The legendary siblings beat Sara Errani and Kirsten Flipkens 6-4 6-2 in front of a packed crowd on Court 7. After 3 hours and 54 minutes, Zverev beat the opponent 3-2 with sets of 6-2, 3-6, 4-6, 7-6 and 7-5 and went on the fourth round.
This is just the second time that Zverev has reached the final 16 at a Grand Slam, after Wimbledon previous year.
In July 2016, Cecchinato was one of three Italian players initially suspended by their national tennis federation for allegedly influencing the outcome of matches.
With the first three matches scheduled on Court Philippe Chatrier all going the distance, Wozniacki did not even make it into the arena till shortly before 7pm local time.
Could this be the turning point for Zverev at Grand Slams? But I think it was a great test.
It might well have been his last visit unless he is planning to hang around, after failing to make the cut in both the men's and mixed doubles.
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World number two and Australian Open champion Caroline Wozniacki continued her impressive run in Paris with a 6-0 6-3 win over local hope Paul Parmentier in the third round.
The win notches up the 33rd tour-level victory for Zverev this year, more than any other player.
In the end, he held his own and went on to register a 6-2 3-6 4-6 7-6 (7-3) 7-5 victory in just under four hours.
The 34-year-old Verdasco will next face either his compatriot Roberto Bautista Agut or former champion Novak Djokovic for a quarter-final spot.
French Open second seed Alexander Zverev faced the media in Paris following his second-round victory in the Grand Slam tournament - and began by taking questions from Live Sports FM journalist Jonathan Pinfield, who is from Bradford. With that said, I just can't bet against the German.
"I'm trying to win matches", a defensive Zverev said at a post-match press conference.
Zverev wasn't the lone large title to be stretched within the males's backside half, with Grigor Dimitrov - who gained the year-end championships in 2017 - and 2014 US Open finalist Kei Nishikori additionally overturning 2-1 deficits in units. Donaldson had been dealing with leg cramps all set, and they seemed to have ended his match at 7-7. But Buzarnescu fought back to break Keys and then clenched her fist after holding for 5-4.
Ahead 5-4 in the fifth, Dzumhur was one point from winning while Zverev served at 30-40.